Formulation and Stability of the Antineoplastic Agent: N, H-Di-9-AcridinylHexanediamine (Nsc 1219733)

Abstract

N, N-di-9-acridinvl-l, 6-hexanediamine- (MSC 1219733) was solubilized and lyophilized for parenteral use in the form of the methanesul fonate salt. Stability studies of the drug in solution of pll 3.0, 4.5 and 7.0.and at both 25° and 70°C were carried out and the drug was stable at 25°. At 70°C sliqht degradation was observed, in solutions of pH 3.0 and 4.5, while extensive loss occurred at pH 7.0 with a half-life of 16.5 hours. The lyophilized preparation was stable for one week when reconstituted with water and diluted with 5% dextrose solution. Precipitation of the drug as the hydrochloride salt occurred when dilution was done with normal saline solution. Stability was monitored using high performance liquid chromatography.