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Abstract
The subject of the study is a cooperative evaluation of the properties of different disintegrants: starches (corn, maize, potatoe, rice) and derivatives (STARX 1500, carboxymethylstarches as PRIMOJEL or EXPLOTAB); celluloses (AVICEL, ELCEMA) and derive ted products as methylcellulose (METHOCEL), carboxymethylcellu-lose (sodium salt, NYMCEL, AC DI SOL), low substituted hydroxy-propylcellulose (L-HPC); macromolecules (Alginic acid, AMBERLITE IRP 88, ESMA SPRENG, Pectins, a.s.o.); finely divided solids (AEROSIL, VEEGUM). To realise this comparative study, different methods of evaluation of disintegrants physical properties are choosen, and wettability (contact angle), water uptake and swelling of the products measured. The disintegrants are also included in a calcium phosphate based tablet formula, and the disintegration is studied. The mechanism of action of the disintegrants is shortly discussed, and an approximate price/efficiency ratio given.
The results of the work permit a better choice of an appropriated disintegrant.
Purpose of tablets formulation is now Co obtain very short disintegrating times so that to that liberation of drug can begin without delay as soon as tha tablet is in contact with gastric juice.
Therefore, it is now iaportant to look for the sure efficient disiutugrauts, and so, many Materials are avalaible from industry.
Purpose of present study was to compare some physical properties of these different disintegranta.