Preformulation Studies III - Vasicinone - a Bronchodilatory Alkaloid from Adhatoda Vasica Nees (Absorption, Potency and Toxicity Studies)

Abstract

Bronchodilatory activity of pure samples of vasicinone hydrochloride is investigated and compared with isoprenaline and aminophylline. Acute toxicity in mice and absorption pattern in dogs of aqueous solution administered by different routes is studied. The studies confirm the activity and safety of vasicinone and its potentiating effect on bronchodilatory activity of aminophylline.