Increasing the Dissolution Rate of some Benzothiadiazine Derivatives by Solid and Liquid Dispersion Techniques

Abstract

Dissolution rates of water-insoluble drugs such as Chlorothiazide, Hydrochlorothiazide, Flumethiazide and Cyclopenthiazide were markedly increased when dispersed in polyethylene glycol 6000. The increased dissolution rate was believed to be attributed to the molecular and for the colloidal dispersion of the drug in the matrix of PEG 6000. Bendroflumethiazide and Methylclothiazide were found to be decomposed by either of dispersion techniques.