Hydrate Related Dissolution Characteristics of Norfloxacin

Abstract

The effect of moisture and temperature on the physical and chemical stability of solid oral dosage forms of Norfloxacin was studied. The physical properties of the dosage form, i. e. breaking strength and disintegration time were not affected adversely. Dissolution characteristics of Norfloxacin tablets were found to be affected by humidity conditions. Tablets with poor dissolution characteristics were improved to satisfactory rates by exposure to 21–25°C/75% relative humidity. Exposure to lower humidities and higher temperatures adversely affected dissolution rates. Once favorable dissolution rates were attained, however, they remained unchanged in spite of dehydration of the tablets.