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Abstract
The stability of Panthenol,Chlorphenesira and Lignocaine was determined in solidified sodium stearate-based sticks over an 18 months period. Panthenol was determined spectrophotomet-rically as pantonyl lactone,at 250 nm,after separation of any interfering substances on a double bed chromatographic column containing Dowex 50W-X4 resin on top of Amberlite G400 resin. Chlorphenesin was determined spectrophotometrically at 280 nm wavelength after extraction with chloroform to separate any degradation products. Lignocaine was determined spectrophotometrically at 420 nm wavelength,as its Bromocresol green complex in chloroform,after extraction with the latter solvent from the solution of the stick in acid phthalate buffer at a pH of 4,2.
The obtained results pointed out to the very high stability of these drugs in the studied dosage form. This was mainly attributed to the high alcohol and low water contents of the sticks besides their thixotropic nature.