Effect of Particle Size and Excipients on the Dissolution Rate of Metronidazole from Solid Dosage Forms: I

Abstract

The use of metronidazole in the treatment of Trichomoniasis, Giardiasis, Amoebiasis and infections caused by anaerobic microbes has been well established. This communication outlines efforts made to design a metronidazole formulation with better absorption properties than the “KLION-Tablet”, currently manufactured by the Chemical Works of Gedeon Richter Ltd., Budapest, A relatively low solubility of the drug in water, and improper selection of vehicles contribute to low dissolution rate, hence limiting the absorption. Particle size reduction and the incorporation of lactose in the finer aggregating powder, showed increased dissolution rate.