Abstract
Serum levels of lignocaine in ten healthy volunteers were determined after peri-oral injection of 36 mg lignocaine hydrochloride. Rapid absorption from injection site occured with a mean peak serum level of 46 ug/ml at 10 minutes.
In addition, lignocaine pharmacokinetics following peri-oral administration were studied. The serum concentration-time data were found to obey the one-compartment open model adequately with first-order absorption and elimination rates.