Studies on Sustained Release II: in Vivo Performance of the Inert Matrix Sulfamethizole Tablet, Employing Polymethylmethacrylate

Abstract

The in vivo performance of the developed sustained release preparation was assessed on eight subjects. Based upon urinary excretion rates, in vivo data supported previous in vitro dissolution test results. An overall release/excretion rate of 32.6 mg/hr was obtained. The blood levels were assayed for intact drug and were fit to a three exponential equation employing the program AUTOAN. First order release rate constant of 1.33 hr was calculated, but the fits were not very satisfactory Although the blood levels were in an acceptable range, it is concluded that a faster releasing dosage form would be more appropriate This might require however, switching to another dosage form.