Surface Characterisation df Sucrose and Antibiotics Powder Mixes with Relevance to Mixing Theories

Abstract

Adhesional ordered mixing is not applicable in real systems because ordered interaction between drug and excipient particles can not be achieved. In contrary, Interactive Mixture approach is more applicable because it allows the powder mixtures to be described according to the state of homogeneity achieved which is dependent on mixing variables.

Surface characteristics of powder mixture particles are important to study in order to understand the interparticulate interactions between drug and excipient particles.

Indentations on excipient particles act as mechanical entrapment sites for drug particles which result in areas containing highly localised drug content. Consequently, the state of homogeneity of powder mixtures is possibly affected. Furthermore, the release of particles which are entrapped will be different from those held by interparticulate forces on the plain surfaces of excipient particles. This is particularly important when the excipient particles are insoluble and drug particles are poorly soluble.