Processing Factors Influencing the Stability of Freeze Dried Sodium Ethacrynate

Abstract

The transitions observed in D.T.A. and E.C. profiles of aqueous sodium ethacrynate systems confirmed their potential to produce different physical forms of drug during freeze drying. The stability of freeze dried preparations was found to be related to the freezing rate, the concentration of sodium ethacrynate in the pre-lyophilised solution and the fill volume of solution. The stability profiles of the freeze dried preparations were related to the physical form of the drug and the production of a liquid degradation product.