Evaluation of Pentaerythritol (Rosin) Estergum as Coating Materials

Abstract

Rosin was heated with pentaerythritol and intermediate reaction products with the different acid values were obtained. Their physical properties were studied. Aspirin granules were coated with these coating materials. Coated drug granules were evaluated for moisture absorption, flow properties, friability loss and dissolution studies in gastric medium and intestinal medium. The results have shown that these coating materials have excellent film forming properties and impart moisture protective coatings, The dissolution studies revealed that these exhibit different degree of resistance to gastric and intestinal pH's and can be used for delayed release of drug. The study of the dissolution kinetics revealed that the release characteristics obey the Hixson-Crowell cube root dissolution law and the values of cube root dissolution constants have been reported.