Abstract
Medazepam, the well known benzodiazepine derivative used as a transquillizer and in alcohol withdrawal, was prepared in directly compressed tablets. The directly compressible vehicles which were used. singly or in binary blends 1:1, were Avicel, Lactose, STA-Rx 1500 Emcompress and the recently introduced vehicle compactrol. It was found that Avicel and Emcompress represent the most suitable single vehicles used for the preparation of Medazepam hydrochloride tablets. In case of binary blends it was found that the best quality batches were prepared using Avicel Emcompress blend 1:1. Physical characteristics including uniformity of weight, thickness, hardness, friability were investigated for the prepared batches. The effect of directly compressible vehicle variation on the uniformity of drug content and the dissolution rates of Medazepam hydrochloride tablets was also studied.