20
Views
8
CrossRef citations to date
0
Altmetric
Research Article

Advantages of the Use of Very Short and Ultra Short Hplc Columns for Drug Analysis in Dissolution Testing

Pages 2301-2312 | Published online: 20 Oct 2008
 

Abstract

The advantages of short (3–5cm long) or ultra short (4mm long) HPLC columns for drug analysis in dissolution testing are illustrated by reference to some example antihypertensive drug formulations.

Advantages include: selectivity, where interfering excipients or co-formulated drugs complicate UV spectrophotometric analysis: time savings, compared with conventional HPLC columns (although where UV spectrophotometry is applicable no time advantages may be obtained with short column HPLC): economy, as the columns are less expensive than conventional columns and there is reduced solvent consumption: increased sensitivity compared with conventional columns. Low dose potent. drugs with poor chromophores may be more readily quantitated: amenity to automation, including the use of laboratory robots.

These advantages would suggest the wide applicability to this mode of analysis in dissolution testing.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.