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Abstract
The liberation of a drug from an inert matrix tablet is usually studied by plotting the percentage of drug released as a function of the square root of time, according to the equation proposed by Higuchi for the mechanism of drug release. In many cases this plotting does not give a straight line during al. 1 the liberation. In this paper matrices containing metoclopramide as an active drug and ethylcellulose as a polymer have been studied, and the origin of the non linear release at the end of the liberation discussed.