Biopharmaceutical Study of Glybornuride-Polyethylene Glycol Systems

Abstract

Glybornuride is an oral hypoglucaemiant drug which exhibits a very low water solubility. Consequently,the solid dispersions of this drug with PEG 6,000; 10,000 and 20,000 have studied. According to the phase diagrams obtained, the following solid dispersions of glybornuride were prepared: at 30% with PEG 6,000 and 10,000 and 40% with PEG 20,000.Dissolution curves show that glybornuride dissolves faster as solid dispersion, particularly with PEG 6,000. The administration of glybornuride as a solid dispersion into rabbits induced a faster decrease of glucaemia levels than a physical mixture with polyethylene-glycols.