In-Vivo Evaluation of Commercial and Formulated Conventional Aspirin Tablets

Abstract

In-vivo evaluation of eight brands of conventional aspirin tablets (six commercial brands and two prepared formulae) was assessed in six healthy subjects. Measurements of urinary salicylate excretion were carried out using the method of Chiou and Onyemelukwe in which a proposed reagent was used instead of Trinder's reagent for the assay of total salicylate in urine. The bioava-ilability parameters of the studied brands were calculated. Out of all the studied commercial brands, brand A showed the best results while brand D showed the worst. A prepared formula (Y) was found to superior over all the commercial brands concerning their bioavailability. The inclusion of a surfactant in formula Y was found to be the main reason for absorption enhancement. The pharmacokinetic parameters of the six subjects for the different brands were also computed. A marked intersubject variation for bioavailability and pharmacokinetic parameters was observed.