Evaluation of Dika Fat as a Suppository Base

Abstract

Dika fat, a solid vegetable fat, derived from the seeds of Irvingia qabonensis was evaluated as a suppository base for aspirin, aminophylline and chloroquine phosphate. The result show that the suppositories formulated with dika fat blends satisfied the pharmaceutical requirements of drug release and stability. A change in colour observed with aminophylline preparations may be due to a physical interaction between the drug and base. The observed change in colour did not however change the in vitro release of the drug.