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Drug Development and Industrial Pharmacy Volume 15, 1989 - Issue 1
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Research Article

Effect of Compaction Speed and Die Diameter on Athy-Heckel and Hardness Parameters of Compressed Tablets

K. Danjo Meijo University, faculty of Pharmacy, Tempaku-cho, Tempaku-ku, Japan
,
Carolyn Ertell Stauffer Chemical Company, Elmsford, NY, 10523, USA
&
J. T. Carstensen School of Pharmacy, University of Wisconsin, 425 North Charter Street, Madison, Wisconsin, 53706, USA
Pages 1-10 | Published online: 20 Oct 2008
 
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Abstract

It is shown that within experimental error Athy-Heckel plots of extruded tablets are independent of (a) die fill, (b) die diameter, and (c) punch speed in slow, single-sided compression. Stress at failure is shown to be porosity dependent.

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