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Drug Development and Industrial Pharmacy Volume 15, 1989 - Issue 1
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Research Article

Effect of Drug Solubility in Wet Granulation Fluids on the Dissolution Rates of the Resulting Tablets

P. Wu Merrell-Dow Research Institute, Indianapolis, IN, 46268
,
F. Attarchi Merrell-Dow Research Institute, Indianapolis, IN, 46268
,
N. Anderson Merrell-Dow Research Institute, Indianapolis, IN, 46268
&
J. T. Carstensen School of Pharmacy, University of Wisconsin, Madison, WI, 53706
Pages 11-16 | Published online: 20 Oct 2008
 
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Abstract

One factor in wet granulation processes which affects dissolution rates of the final tablets is shown to be the solubility of the drug substance in the granulating liquid. The relationship is not a direct correlation and a feasible explanation is offered.

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