¹H-Nuclear Magnetic Resonance Spectrosoopic Determination of Haloperidol in Tablets

Abstract

A ¹H-nuclear magnetic resonance spectroscopic method was developed for the assay of haloperiodol in commercial tablets. Dimethylsulfoxide-d_b and 1,4-dinitrobenzene were used as the solvent and the internal standard, respectively. Recovery values of haloperidol (mean ± SD) from synthetic formulations were 99.8 ± 0.86% (CV = 0.86%, n = 10) by the proposed method, and 99.6 ± 0.80% (CV = 0.80%, n = 3) by the attrimetric method of USP XXI. Assay results for commercial 10 and 20 mg tablets agreed closely with those obtained by the compendial spectrophotometric method.