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Research Article

Counting of Microspheres in Electrolytes and Parenteral Solutions

, &
Pages 2441-2454 | Published online: 20 Oct 2008
 

Abstract

The counts of microspheres in 20 testing solutions were determined using 2 Coulter Counters (electrical resistance) and 2 HIAC/Royco (light blockage) particle analysers. The mean cumulative number of microspheres (≥2μm) in unit volume of the solutions determined using the Coulter Counters was higher than those determined by HIAC/Royco particle analysers. The mean cumulative counts obtained by the two Coulter Counters are similar; however, t-test analysis shows significant difference for the counts of 8 different types of solutions. The mean cumulative counts obtained by the two HIAC/Royco Counters varied greatly and t-test analysis showed that 18 out of 20 of the solutions gave significant difference

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