Volume/Surface Weighted Mean Diameter as an Indicator of Dissolution Rate

Abstract

The dissolution rate of a batch of drug substance is related to its intrinsic dissolution rate and particle size distribution. For dissolution purposes, the volume/surface weighted mean diameter (d_vs) appears to be the best descriptor of a batch

Knowledge of the intrinsic dissolution rate of a compound allows the formulator to set a particle size specification for that compound. This ensures batch to batch consistency of in vitro dissolution performance and affords a high degree of assurance that bioavailability will be maximised

Examples cited are phenacetin, nitrofurantoin, griseofulvin, methylprednisolone and cromakalim