Investigations of the Relationship Between Bowel Derived Organisms and Anorectal Sepsis Pre-Operative and Post-Operative Antibiotic Therapy of the Colon and Rectum

Abstract

The bacteriological study of anorectal sepsis showed that most cultures produced mixed organisms which were either aerobic or anaerobic or both. The most common organisms of perianal abscessess and low fistula were Staph. aureus and B. fragilis while in cases of ischiarectal abscesses and high fistulae, the most common organisms were E. coli and diphtheroids. There was no difference in the bowel derived organism and bacterial species isolated from anorectal sepsis. The organisms causing anorectal sepsis were very sensitive to neomycin sulphate followed by rifampicin. Emulsifying wax ointment base was found to be the best, among the different bases tested, for preparing antiseptic anorectal neomycin sulphate ointment. The bacteriological study of the specimen obtained from 30 patients, before and after preparation showed that the administration of oral and topical neomycin sulphate alone followed by colonic wash was the best while use of oral antibiotics only proved to be of low value. Also, it was found that neomycin sulphate 0.5% w/w in emulsifying wax ointment base and early treatment of anorectal sepsis gave good results