Controlled-Release Matrix Tablets of Ketoprofen

Abstract

To obtain a prolonged-action dosage form of ketoprofen, 3 different techniques for delaying drug release from hydrophylic matrices of hydroxypropylmethylcellulose were evaluated. They were: the incorporation of glyceryl monostearate, as a release retardant; the partial coating with an impermeable covering of cellulose acetate phthalate; the pan-spray coating with a mixture of insoluble (Eudragit) and soluble (PEG 400) polymers. The in vitro release profiles of each formulation were studied using the USP basket method. Pan-spray coating with the Eudragit-PEG mixture was found to be the best technique, enabling the desired release profile to be obtained through variation of the coating thickness