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Abstract
Formalin-casein has been proposed as a tablet disintegrant under the trade name o f Esma-sprenq. The significance of water penetration on the disintegration mechanism has been evaluated by using different tablet constituents and by modifyinq the hydrophobicity inside the tablet. Formalin-casein appears to be a powerful disintegration agent when a sufficiently hydrophobicity network has been created within the tablet. Swelling of the disintegrant has also been considered and evaluated under different conditions. However, this mechanisrn appears to be negligible in the disintegration process. In addition, a number of compressional characteristics were studied.