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Abstract
A simple colorimetric procedure to quantify piroxicam in capsules has been developed. The method is based on the reaction between piroxicam and 4-aminoantipyrine producing an orange color which can be measured at 490 nm. The method is accurate and precise with a percent relative standard deviation of 0.8 based on 5 readings. The results compared very well with the results obtained using the HPLC procedure. The extraction of piroxicam from the capsule powder is very simple which requires only 4 minutes, versus a 30 minute mechanical shaking recommended by the USP-NF. The results of the decomposed samples were similar to the results obtained using the HPLC method.