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Abstract
The effect of compression (30-150 kp/cm2) and diluent (PVP, lactose) on the in vitro release of PASNa from matrix tablets of mastix was evaluated on the basis of different mathematical models. The Higuchi and the exponential model were proved to be the best statistically. It seems that the use of lactose causes an increase on drug release. Also the relationship between the compression and the packing fraction of the tablets was examined. There seems to be a limit point above which no changes in packing fraction occure.