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Abstract
The compression force-time profile parameters proposed by Chilamkurti el al. (1) have proved to be no better than maximum compression force for prediction of the properties of three series of direct compression microcrystalline cellulose tablet formulations containing various proportions of prednisone, phenobarbital or isoniazide and punched under various compression forces. The usefulness of the Chilamkurti parameters is nevertheless not ruled in the case of formulations for which maximum compression force has little predictive value.