Binding Efficiencies of Strach N. F. and Modified Starches in Formulations of Poorly Water Soluble Drugs

Abstract

Active and excipient ingredients were granulated in planetary and high intensity mixers. Compression properties of single and multi-drug formulations were evaluated with an insturmented single punch tablet press interfaced with a digitial computer. Dissolution rates were measured using the USP Apparatus #I. Binding efficiency was found directly proportional to granule coarseness for equally well-lubricated granulations. Some differences were observed between the starches, in the manner of their incorporation (dry or as slurry) and between the single and multi-drug formulations. The fromulations containing the pregelatinized starches allowed faster release of a poorly water soluble drug than did those containing starch, N.F.