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Research Article

Microemulsion for Intradermal Delivery Of Cetyl Alcohol and Octyl Dimethyl PABA

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Pages 899-920 | Published online: 20 Oct 2008
 

Abstract

A water-in-oil microemulsion was prepared to deliver cetyl alchohol [I] octyl dimethyl PABA or Padimate-O [II] in vitro using human and hairless mouse skin. A standard Franz diffusion cell and a microsectiong cryostat microtome were used to quantify the rate and the depth of penetration and the results were compared in the percent does penetrated for this microemulsion and two macroemulsion formulations, namely a cream and a lotion. It appeared that the microemulsion had the ability to deliver [I] into the skin 2-6 times faster and at least twice as much as that with the other two formulations. Furthermore, the absorption of [I] from the cream or lotion product could bel enhanced by as much as 50-250% if the skin had been pretreated with microemulsion prior to product application. The advantage of using a microemulison to acheieve deeper and faster penetratin of the permeating compunds was clearly demonstreated in this study.

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