The swelling of core tablets during aqueous coating II: An application of the model describing extent of swelling and water penetration for insoluble tablets

Abstract

A mathematical model successfully describing the extent of swelling and water penetration for dicalcium phosphate dihydrate(Ditab) tablets is able to be applied to the anhydrous form. The extent of swelling/water penetration behavior exhibited by anhydrous dicalcium phosphate(ATAB) is quite different from that of dihydrate form, which exhibits non-swelling. More water tends to penetrate into ATAB tablets than those tablets prepared from Ditab. The water uptake is coincident to the very large surface tablet porosity.