Influence of technological variables on release of drugs from hydrophilic matrices

Abstract

Hydrophilic matrices are an interesting option when developing an oral sustained-release formulation. Entering the field of pharmaceutical technology almost 40 years ago, they have been steadily growing as regards applications, largely as a result of the increasing need for suitable polymers. Recently, the physico-chemical mechanisms implied in controlling release from such systems have been subjected to new studies, providing the basis for en interpretation of the many deta concerning the dependence of the behaviour of these systems with respect to the technological variables involved in the processes used in their fabrication. It is from this viewpoint that this article analyzes bibilographic information and considers the possibilites for modulating release of drugs of high end low solubility through control of their physical properties, the correct choise of gelling agent and correctly setting up the conditions for fabrication.