Application of Percolation Theory and Fractal Geometry to Tablet Compaction

Abstract

Percolation theory¹ and fractal geogetry² represent novel powerful concepts which cover a wide range of applications in pharmaceutical technology³. Both concepts provide new insights into the physics of tablet compaction and the properties of compacts^4-11. The paper reviews and summarizes the most recent findings in the application of percolation theory and fractal geometry to tablet compaction which include four sections i.e. 1) short introduction to percolation theory and fractal qeometrv, 2) the formation of a tablet^{4, 7, 10}, 3) tablet properties such as deformation hardness, tensile strength¹⁰ and 4) drug dissolution from a matrix type controlled release system^{3, 9, 11}.