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Abstract
When drugs particles are very hydrophobic, the carrying out of solid dispersion is a good process in order to obtain a faster drugh dissolution due to the particle the particle size reduction and due to the wettability improvement of the particle surfaces.
The behaviour of these products may differ according to their physical structure, more particularly the dissolution rate of the drug and the stability of the solid dispersion obtained.
The aim of this work is
— to study a product supplied by industry, that is to say a Coprecipitate obtained by evaporation of an ethanolic Oxodipin/Povydone solution. The high melting point of Oxodipin has conduct us to choose coprecipitation. The oxodipin amount in the coprecipitate (20%), is a good compromise between efficiency and technological properties.
— to demonstrate that the product obtained is a solid dispersion.
— to test its stability during compression and during the stockage ether in ambient condition, or at 40° C, or in controled humidity conditions.
Results seem to demostrate that a solid disperision which is a solid solution is obtained. This solid dispersion presents a very good stability of its physical structure and of dissolution properties.