Design of Redispersible Dry Emulsion as an Advanced Dosage Form of Oily Drug (Vitamin E Nicotinate) by Spray-Drying Technique

Abstract

An oily drug, dl-α-tocopherol nicotinate (VEN) was transformed to the newly developed powdered form, termed dry emulsion, by spray-drying the emulsified VEN or oily solutions of VEN with additives. The drug releasing property from the resultant particles was dependent on various factors such as the emulsifying method and the type and amount of the oily carrier and surfactant formulated. The desired releasing property was offered by use of medium chain triglyceride (MCT) as the oily carrier and polyoxyethylene-polyoxypropylene-blockcopolymer (Pluronic F-68) or polyoxyethylenesorbitan monolaulate (Tween 80) as the emulsifying agent. The difference in drug releasing property with various formulations was found to be mainly attributed to the difference in physical state of VEN surfactant in the dry emulsion particle, which was detected by differential scanning calorimetry.