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Abstract
An in-depth evaluation of the adsorption of Devazipide onto microcrystalline cellulose, formulation and/or process optimization procedures to minimize this adsorption are reported. This adsorption was more evident in the 1 mg compared to the 10 mg strength tablet and could be completely eliminated if the microcrystalline cellulose was reduced to <10%. This adsorption followed the Langmuir Isotherm and was dependent on pH with insignificant amount of adsorption occurring at pH 2.0. At this particular pH, adsorbed drug is easily released.