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Abstract
The effects of polyethylene glycol (used as suppository base), a surfactant (Polyoxyl 59 stearate - Myrj 59®) and phenytoin on the rectal mucosa of the rat were investigated. Four different types of effects were observed in the 52 rats treated with the various polyethylene glycol, surfactant and phenytoin combinations. Polyethylene glycol had a definite necrotic effect on the rectal mucosa of the rat. This adverse effect was more pronounced when phenytoin and polyoxyl 59 stearate were combined with the polyethylene glycol.