The Taguchi's Performance Statistic to Optimize Theophylline Beads Production in a High-Speed Granulator

Abstract

An original process using a simple procedure is developed to produce theophylline active pellets. In order to improve this process, an optimization approach is applied. But rather than only trying to bring the process to the target optimal values, attempt is made to find operating conditions leading also to stable and non-sensitive pellets characteristics. In this purpose, the classic experimental design approach and response surface methodology are completed by using Taguchi's philosophy.