Morphological and Fractal-Based Methods Describing Insulin Zinc Crystal Habits

Abstract

Computerized image analysis was used to obtain Fourier contour parameters and the fractal dimension of insulin zinc crystals (IZC). These methods are capable of characterizing and identifying small changes in the morphological and surface parameters of IZC with different crystal habits during dissolution. The Fourier contour analysis and the fractal dimension measurement technique described in this report could be useful tools to control batch-to-batch variations and to predict differences in the dissolution behaviour of IZC with different crystal habits.