Effect of Polymerization Coadjuvants on Nanocapsule Elaboration and Triamcinolone Entrapment

J. Valero Department of Pharmacy, Physicochemical Unity, Faculty of Pharmacy, Avda. Diagonal s/n, Pedralbes, 08028, Barcelona, Spain

M. A. Egea Department of Pharmacy, Physicochemical Unity, Faculty of Pharmacy, Avda. Diagonal s/n, Pedralbes, 08028, Barcelona, Spain

M. Espina Department of Pharmacy, Physicochemical Unity, Faculty of Pharmacy, Avda. Diagonal s/n, Pedralbes, 08028, Barcelona, Spain

F. Gamisans Department of Pharmacy, Physicochemical Unity, Faculty of Pharmacy, Avda. Diagonal s/n, Pedralbes, 08028, Barcelona, Spain

M. L. Garcia Department of Pharmacy, Physicochemical Unity, Faculty of Pharmacy, Avda. Diagonal s/n, Pedralbes, 08028, Barcelona, Spain

Abstract

The physical and chemical properties of tramcinolone acetonide nanocapsules, prepared by interfacial polymerization of isobutyl-2-cyanoacrylate at the oil/water I interface, have been studied. The joint effect of monomer and oil in organic phase on the size and encapsulation efficiency has been analyzed. Polymer coating around the oil droplets causes an important variation in droplet size and encapsulation efticiency. The release of drug from the nanocapsules was also investigated in vitro.

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Effect of Polymerization Coadjuvants on Nanocapsule Elaboration and Triamcinolone Entrapment

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Effect of Polymerization Coadjuvants on Nanocapsule Elaboration and Triamcinolone Entrapment

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