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Abstract
The in vitro iontophoretic delivery of timolol maleate (TM) was carried out using a modified two-chambered, horizontal diffusion cell. The effect of various electrical factors on iontophoretic permeation of drug was analyzed. The iontophoretic permeation of TM through human cadaver skin was more greatly enhanced than the passive permeation. The increase in current intensity linearly increased the permeation of drug. The sine wave form showed the highest permeation than other wave forms used. Pulsed mode iontophoresis seems to be more efficient than constant current drug permeation through skin.