Effect of Temperature on Characteristics of Hydroxypropylcellulose Tablets Prepared by Wet Granulation Methods

Abstract

In this work, we will study the effect of temperature (35-45°C) on the disintegration and dissolution rate of theophylline from the tablets containing hydroxypropylcellulose as a binder (binder in solution). The results showed that in all cases the increase of the temperature led to the acceleration of the disintegration and the dissolution rate of theophylline tablets except in basic formula. The disintegration and dissolution times decrease gradually, then abruptly fall in time at the demixing temperature and take the same time as the basic formula. It was alsom observed that the demixing temperature varies with the concentration of the polymer in the tablet formulation and shows no change in rheological formulation