Percutaneous Absorption of Captopril from Hydrophilic Cellulose Derivatives Through Excised Rabbit Skin and Human Skin

Abstract

The purpose of this investigation was to evaluate the influence of percutaneous absorption of captopril from hydrophilic cellulose derivatives gel bases (carboxym-ethylcellulose sodium [CMC], hydroxypropylcellulose [HPC] and hydroxylpropyl-methylcellulose [HPMCJ. The effects of various types and concentrations of penetration enhancers on captopril percutaneous absorption from HPC gel through rabbit skin were evaluated and selected to obtain some optimal formulations for penetration study through human chest skin. Then the required flux (1488 µg/hr) for captopril transdermal drug delivery system to maintain the therapeutic minimum effective concentration through human skin was used to evaluate the development of the optimal formulations. The results indicated that the minimum administered areas for therapeutic minimum effective concentration of captopril (cap) gel containing decanol (dec) were 10.4 cm² (5% cap, 7% dec) and 7.6 cm² (7% cap, 7% dec). These areas were within acceptable range, so these formulations can possibly be developed for a transdermal drug delivery system.