Evaluation of a Sulfobutyl Ether β-Cyclodextrin as a Solubilizing/Stabilizing Agent for Several Drugs

H. Ueda Department of Physical Chemistry, Hoshi University, 4-41, Ebara 2-chome, Shinagawa-ku, Tokyo, 142, Japan

D. Ou Department of Physical Chemistry, Hoshi University, 4-41, Ebara 2-chome, Shinagawa-ku, Tokyo, 142, Japan

T. Endo Department of Physical Chemistry, Hoshi University, 4-41, Ebara 2-chome, Shinagawa-ku, Tokyo, 142, Japan

H. Nagase Department of Physical Chemistry, Hoshi University, 4-41, Ebara 2-chome, Shinagawa-ku, Tokyo, 142, Japan

K. Tomono College of Pharmacy, Nihon University, 7-1, Narashinodai 7-chome, Funabashi-shi, Chiba, 274, Japan

T. Nagai Faculty of Pharmaceutical Sciences, Hoshi University, 4-41, Ebara 2-chome, Shinagawa-ku, Tokyo, 142, Japan

Abstract

To evaluate the potential use of β-cyclodextrin sulfobutyl ether, 7 sodium salt (SBE7-β-CD) as a drug solubilizing and stabilizing agent, the solubilizing effects of SBE7-β-CD on 22 different poorly water-soluble drugs were compared with those of intact β-CD and heptakis-(2,6-di-O-melhyl)-β-CD (DMCD). SBE7-β-CD was generally a more effective solubilizer for poorly water-soluble drugs than was intact β-CD, but SBE7-β-CD was not as effective as DMCD. The effects of SBE7-β-CD on the acid hydrolysis rate of prostaglandin I₂, the alkaline hydrolysis rate of indomethacin, the dehydration of prostaglandin E₁, and the isomerization of prostaglandin A₁ were also investigated and compared to those for intact β-CD, DMCD, and 2,3,6 partially methylated-β-CD (PMCD). The stabilizing effects of SBE7-β-CD on chemically unstable drugs were generally higher than those of other CDs.

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Evaluation of a Sulfobutyl Ether β-Cyclodextrin as a Solubilizing/Stabilizing Agent for Several Drugs

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Evaluation of a Sulfobutyl Ether β-Cyclodextrin as a Solubilizing/Stabilizing Agent for Several Drugs

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