Manganese Superoxide Dismutase Expression as a Function of Genotype and Lung Cancer Pathology

Robert C. G. MartinDepartments of Surgery, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky, USA,and Pharmacology & Toxicology,James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky, USACorrespondence[email protected]

Yan LiDepartments of Surgery, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky, USA,and Pharmacology & Toxicology,James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky, USA

Qiahong LiuDepartments of Surgery, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky, USA,and Pharmacology & Toxicology,James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky, USA

David F. BarkerDepartments of Surgery, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky, USA,and Pharmacology & Toxicology,James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky, USA

Mark A. DollDepartments of Surgery, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky, USA,and Pharmacology & Toxicology,James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky, USA

David W. HeinDepartments of Surgery, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky, USA,and Pharmacology & Toxicology,James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky, USA

ABSTRACT

Introduction: The aim of this study was to compare the manganese superoxide dismutase (MnSOD) expression in matched tumor and normal tissue. Methods: One hundred lung cancer specimens and matched normal lung parenchyma from the same patient were evaluated for MnSOD expression. Results: The median normal MnSOD expression was 42% with a range of 10 to 70%, which was significantly greater (p = .001) than the median MnSOD expression in the tumor samples that was 18.8% and ranged from 1.1 to 50%. Conclusion: MnSOD expression is significantly reduced in lung adenocarcinoma and squamous cell carcinoma compared to the matched normal lung tissue.

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Manganese Superoxide Dismutase Expression as a Function of Genotype and Lung Cancer Pathology

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Manganese Superoxide Dismutase Expression as a Function of Genotype and Lung Cancer Pathology

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