Expression and Mutation Analysis of Her2 in Head and Neck Squamous Cell Carcinoma

Mahmoud AL Sheikh AliDepartment of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan

Mehmet Gunduz

Esra Gunduz

Ryo TamamuraDepartment of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan

Levent Bekir BederDepartment of Otolaryngology Head and Neck Surgery, Wakayama Medical University, Kimiidera, Wakayama, Japan

Naoki KataseDepartment of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan

Omer Faruk HatipogluDepartment of Molecular Biology and Biochemistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan

Kunihiro FukushimaDepartment of Otolaryngology Head and Neck Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan

Noboru YamanakaDepartment of Otolaryngology Head and Neck Surgery, Wakayama Medical University, Kimiidera, Wakayama, Japan

Kenji ShimizuDepartment of Molecular Genetics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan

Hitoshi NagatsukaDepartment of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan

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ABSTRACT

We analyzed mutation and expression status of human epidermal growth factor receptor 2 (Her2) in head and neck squamous cell carcinoma (HNSCC) using single strand conformation polymorphism (SSCP) mutation analysis and immunohistochemistry (IHC). Mutations were absent in all 85 cases. Out of 57 cases available for IHC, Her2 protein expression was negative (0) in 40 tumors (70%). Seventeen tumors (29.8%) expressed Her2, among these 13 tumors (22.8%) showed a weak (+1) expression and 4 (7%) showed a moderate expression (+2), none showed a strong (+3) expression. There was not a significant association between expression and any of the patients’ clinical variables or prognosis. Our results suggest that Her2 may not be useful as a molecular target in HNSCC.

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Expression and Mutation Analysis of Her2 in Head and Neck Squamous Cell Carcinoma

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