Low Energy Proton Beam Induces Efficient Cell Killing in A549 Lung Adenocarcinoma Cells

Somnath GhoshRadiation Biology and Health Sciences Division, Radiological Physics and Advisory Division, Nuclear Physics Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India

Nagesh N. BhatRadiation Biology and Health Sciences Division, Radiological Physics and Advisory Division, Nuclear Physics Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India

S. SantraRadiation Biology and Health Sciences Division, Radiological Physics and Advisory Division, Nuclear Physics Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India

R. G. ThomasRadiation Biology and Health Sciences Division, Radiological Physics and Advisory Division, Nuclear Physics Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India

S.K. GuptaRadiation Biology and Health Sciences Division, Radiological Physics and Advisory Division, Nuclear Physics Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India

R.K. ChoudhuryRadiation Biology and Health Sciences Division, Radiological Physics and Advisory Division, Nuclear Physics Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India

Malini KrishnaRadiation Biology and Health Sciences Division, Radiological Physics and Advisory Division, Nuclear Physics Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India

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ABSTRACT

The aim of the current study was to determine the signaling differences between γ- and proton beam-irradiations. A549 lung adenocarcinoma cells were irradiated with 2 Gy proton beam or γ-radiation. Proton beam was found to be more cytotoxic than γ-radiation. Proton beam-irradiated cells showed phosphorylation of H2AX, ATM, Chk2, and p53. The mechanism of excessive cell killing in proton beam-irradiated cells was found to be upregulation of Bax and downregulation of Bcl-2. The noteworthy finding of this study is the biphasic activation of the sensor proteins, ATM, and DNA-PK and no activation of ATR by proton irradiation.

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Low Energy Proton Beam Induces Efficient Cell Killing in A549 Lung Adenocarcinoma Cells

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Low Energy Proton Beam Induces Efficient Cell Killing in A549 Lung Adenocarcinoma Cells

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