ZBTB7 Overexpression Contributes to Malignancy in Breast Cancer

Hongyan QuDepartment of Abdominal Surgery, The Tumor Hospital of Harbin Medical University, Harbin 150081, China

Danni QuDepartment of Obstetrics and Gynecology, Beijing Chao-Yang Hospital, Capital University of Medical Sciences, Beijing 100020, China

Fuhui ChenDepartment of Respiratory Diseases, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China

Zhenyu ZhangDepartment of Obstetrics and Gynecology, Beijing Chao-Yang Hospital, Capital University of Medical Sciences, Beijing 100020, China

Baogang LiuDepartment of Abdominal Surgery, The Tumor Hospital of Harbin Medical University, Harbin 150081, China

Haifeng LiuDepartment of Abdominal Surgery, The Tumor Hospital of Harbin Medical University, Harbin 150081, China

ABSTRACT

ZBTB7 was recently recognized as a proto-oncogene. We studied its prognostic value and relationship to clinicopathological variables in 125 breast cancer patients. ZBTB7 expression was significantly higher in breast cancer tissues than in normal breast tissues, but its gene amplification copies were relatively low. ZBTB7 expression levels were significantly correlated with histological grade (p = .023) and marginally inversely correlated with the presence of estrogen receptors (p = .053); its overexpression significantly predicted shorter recurrence-free survival (p = .033). Our results showed that ZBTB7 might be implicated in breast cancer development and may serve as a promising prognostic marker.

Keywords: :

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

ZBTB7 Overexpression Contributes to Malignancy in Breast Cancer

Information for

Open access

Opportunities

Help and information

ZBTB7 Overexpression Contributes to Malignancy in Breast Cancer

ABSTRACT

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature