Cleft Lip and Palate in Family Members of Cancer Survivors

E. TaioliDepartment of Epidemiology, SUNY Downstate Medical Center, Brooklyn, New York, USA, Department of Medicine, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA Center for Research on Healthcare, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA, Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

C. RaginDepartment of Epidemiology, SUNY Downstate Medical Center, Brooklyn, New York, USA, Department of Medicine, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA Center for Research on Healthcare, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA, Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

L. RobertsonDepartment of Epidemiology, SUNY Downstate Medical Center, Brooklyn, New York, USA, Department of Medicine, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA Center for Research on Healthcare, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA, Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

F. LinkovDepartment of Epidemiology, SUNY Downstate Medical Center, Brooklyn, New York, USA, Department of Medicine, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA Center for Research on Healthcare, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA, Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

N.E. ThurmanDepartment of Epidemiology, SUNY Downstate Medical Center, Brooklyn, New York, USA, Department of Medicine, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA Center for Research on Healthcare, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA, Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

A.R. VieiraDepartment of Epidemiology, SUNY Downstate Medical Center, Brooklyn, New York, USA, Department of Medicine, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA Center for Research on Healthcare, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA, Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

ABSTRACT

The presence of cleft lip with or without cleft palate (CL/P) in family members of cancer patients was investigated. An epidemiological questionnaire including family history of cancer and congenital oral cleft malformations was administered to 168 cancer survivors and a population-based sample of 170 healthy subjects. In the control group, 1.2% reported a family member with CL/P; among cancer survivors the figure was 4.2% (odds ratio: 3.7; 95% confidence interval: 0.75–17.8; p = .07). Among cancer survivors with a family member with CL/P, there was an apparent excess of testicular cancer and melanoma in comparison with the cancer survivors with no family history of CL/P. These preliminary results suggest a common etiologic background for cancer and CL/P.

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Cleft Lip and Palate in Family Members of Cancer Survivors

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